姓名： 朱书高

性别：男

职称： 特聘教授

专业： 有机化学

E-mail: shugaozhu@ncu.edu.cn

地址：基础实验大楼B2区701室

研究方向： 活性天然产物及其类似物的合成，过渡金属催化的反应方法学研究，胰岛素类似物的设计合成以及活性研究

科研经历

2019.6- 至今 永利皇宫网页入口化学学院 特聘教授

2017.3-2019.2 University of Utah（犹他大学）博士后 导师：Prof. Danny Hung-Chieh Chou

2015.8-2017.2 Rice University（莱斯大学）博士后 导师：Prof. K. C. Nicolaou

2012.8-2015.6 中科院上海有机化学研究所 博士后 导师： 李昂 研究员

教育背景

2007.9-2012.7 浙江大学理学院 化学系 有机化学博士 导师： 黄宪 教授

2003.9-2007.7 武汉大学化学与分子科学学院 理学学士 导师：周翔 教授

代表性论文：

1. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues.

   K. C. Nicolaou,* P. Chen, ^§ S. Zhu, ^§ Q. Cai, ^§ R. D. Erande, R. Li, H. Sun, K. K. Pulukuri, S. Rigol, M. Aujay, J. Sandoval, and J. Gavrilyuk. J. Am. Chem. Soc. 2017, 139, 15467.

   (^§ these authors contributed equally to this work).

2. Asymmetric Total Synthesis of Lonicerine, Aspidodasicarpine, and the Proposed Structure of Lanciferine.

   Y. Li, ^§ S. Zhu,^§ J. Li, and A. Li*, J. Am. Chem. Soc. 2016, 138, 3982. (^§ these authors

   contributed equally to this work).

   • Top 20 Most Read articles in the year.

• Highlighted by Synfacts 2016, 12, 549.

1. Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7″-epi-C and Full Structural Assignment of Trioxacarcin C.

   K. C. Nicolaou,* Q. Cai, H. Sun, B. Qin, and S. Zhu, J. Am. Chem. Soc. 2016, 138, 3118.

2. Gold-Catalyzed Cyclization of 3-(2′-Azidoaryl)-1-arylpropargyl Carbonates or 3-Aryl-1-(2′-azidoaryl)propargyl Carbonates to Produce Quinolines.

   S. Zhu, L. Wu,* X. Huang, J. Org. Chem., 2013, 78, 9120.

   • Top 20 Most Read articles for the previous month.

3. Synthesis of Polycyclic Isoindoline Derivatives via Tandem Pd-Catalyzed Coupling, Propargyl–Allenyl Isomerization, [4 + 2] Cycloaddition and Aromatization Reaction.

   S. Zhu, J. Cao, L. Wu,* X. Huang, J. Org. Chem., 2012, 77, 10409.

4. Palladium-Catalyzed Sequential Reaction via Sonogashira Coupling, Isomerization, Claisen Rearrangement and [4+2] Cycloaddtion Sequence for the Rapid Synthesis of Tricyclo[3.2.1.0^2,7]oct-3-ene Derivatives.

   S. Zhu, L. Wu,* X. Huang, RSC Adv. 2012, 2, 132.

5. Palladium(0)-Catalyzed Cyclization of Functionalized Propargylic compounds and Tandem Schmittel Cyclization Reaction: A Facile Synthesis of Polycyclic Benzo[b]fluorene Derivatives via Allene Intermediate.

   S. Zhu, L. Wu,* X. Huang, Organic & Biomolecular Chemistry, 2012, 10, 3696.

6. Palladium-Catalyzed Sequential Reactions via Allene Intermediates for the Rapid Synthesis of Fused PolycyclicPyrrole Derivatives.

   X. Huang,* S. Zhu, R. Shen, Adv. Synth. Catal. 2009, 351, 3118.

7. Gold(I)-Catalyzed Decarboxylation of Propargyl Carbonates: Reactivity Reversal of the Gold Catalyst from p-Lewis Acidity to s-Lewis Acidity.

R. Shen,* J. Yang, S. Zhu, C. Chen, L. Wu, Adv. Synth. Catal. 2015, 357, 1257.

1. Chemoselective Synthesis of Highly Substituted 1,2-Allenyl Ketones, Furans, and 2-Alkynyl Ketones from Reaction of Lithium Selenolates with 1-(1-Alkynyl)cyclopropyl Ketones and Electrophiles.

   J. Xu, S. Zhu, L. Wu,* X. Huang, Organic & Biomolecular Chemistry, 2012, 10, 3705.

2. Unexpected Pd-Catalyzed Coupling, Propargyl-Allenyl Isomerization and Alder-Ene Reaction: Facile Synthesis of Some Not Readily Available 2,3-Dihydrofuran Derivatives.

   R. Shen, S Zhu, X. Huang*, J. Org. Chem. 2009, 74, 4118.

3. Pd-catalyzed sequential reaction for the synthesis of fused tricyclic compounds containing a dihydrofuran or isobenzofuranone unit.

   R. Shen, S. Zhu, Q Xia, L. Wu, X. Huang*, Chin. Chem. Lett. 2009, 20, 165.

4. Specific Recognition of Loop DNA by Dicationic Porphyrins.

X. Weng, J. Huang, S. Wu, L. Ren, L. Weng, S. Zhu, X. Zhou*, Chem. Biodiversity. 2007, 4, 1501.

1. Synthesis and Biological Studies of Inducible DNA Cross-Linking Agents.

   X. Weng, L. Ren, L. Weng, J. Huang, S. Zhu, X. Zhou*, L. Weng, Angew. Chem. Int. Ed. 2007, 46, 8020.

   专利：

   1. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogs Thereof.

   K. C. Nicolaou,* P. Chen, S. Zhu, Q Cai. PCT Int. Appl. (2019), WO 2019036537 A1 20190221.